WCN23-0931 A DITERPENE FROM BUDS OF WIKSTROEMIA CHAMAEDAPHNE SUPPRESSES RENAL FIBROSIS VIA BLOCKADE OF WNT/β-CATENIN SIGNALING

Cumulating evidence indicates that chronic kidney disease (CKD) becomes one of the greatest threats to public health, affecting 10% general population globally. Renal fibrosis is hallmark and common pathological feature CKD. However, no treatment targeting renal available so far. To fulfill unmet clinical needs, we screened a series small-molecule diterpene compounds extracted isolated from buds Wikstroemia chamaedaphne, Chinese medicinal herb widely used in folk medicine treat edema hepatitis, found compound15 possessed extraordinary anti-fibrotic activity both vitro vivo.